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יום שלישי, 3 במאי 2011

BMS and Pharmasset to combine BMS-790052 and PSI-7997 HCV DAA candidates for proof-of-concept study...

Pharmasset and BMS initiate first cross-company study combining two QD oral, direct-acting antivirals together both with and without ribavirin.





Bristol-Myers Squibb and Pharmasset are to carry out a proof-of-concept study evaluating their respective investigational drug candidates BMS-790052 and PSI-7977 as oral combination therapy for chronic hepatitis C (HCV). BMS-790052 is BMS’ NS5A replication complex purchase cialis. Pharmasset’s PSI-7977 is a nucleotide polymerase cheap cialis.



The proof-of-concept study will evaluate whether the once-daily oral therapy with the drug duo, either with or without concomitant ribavirin therapy, can lead to a sustained viral response 24 weeks post-treatment in patients chronically infected with HCV genotypes 1, 2, and 3. The trial is expected to start during the first half of 2011. The partners claim it will be the first cross-company study combining two oral, direct-acting antivirals.



At the start of November BMS reported positive data from an open-label Phase IIa trial evaluating a combination of BMS-790052 with its own NS3 protease inhibitor BMS-650032 in HCV genotype 1 patients who had previously not responded to standard HCV therapy with interferon and ribavirin (pegIFNα/RBV). The study showed that when given alongside pegIFNα/RBV treatment, a combination of BMS-790052/BMS-650032 led to 9/10 patients achieving complete early virologic response (cEVR, defined as undetectable viral load) by week 12.



Pharmasset’s PSI-7977, meanwhile, is a uracil nucleotide analog inhibitor of the NS5B polymerase. The drug is currently undergoing Phase IIb evaluation. In December 2010 Pharmasset announced the start of a Phase IIb interferon-sparing trial evaluating PSI-7977 in combination with ribavirin (RBV), and with either 0, 4, 8, or 12 weeks of pegIFNα, as therapy in treatment-naïve patients infected with HCV genotype 2 or 3.



Just last week the firm separately reported positive data from another Phase IIb study, which showed that combining PSI-7977 with pegIFNα/RBV therapy resulted in potent viral suppression in patients with HCV genotype 2 or 3, over 12 weeks. Pharmasset says it plans to initiate a separate Phase IIb combination study during 2011, to evaluate PSI-7977 in combination with pegIFNα/RBV over 24 weeks. PSI-7977 is separately being evaluated in a 14-day Phase I trial as combination therapy with the firm’s guanine nucleotide analog, PSI-938.

Publication: Institute of Beasts

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A new publication by Dutton and Swindells (which includes my essay on their work) will be launched on 15th February 2011 at PSL in Leeds, in conjunction with the artists’ current residency and exhibition at PSL, entitled ‘Stag and Hound’. More about the project can be found at the PSL website here. My essay 'Moves Towards the Incomprehensible Wild' is a version of a much longer essay which will shortly be published in the online journal artandresearch in Volume 4, Number 1, Art and Animality.








About 'Stag and Hound' - artists' statement
'Stag and Hound' is the latest installment of Dutton and Swindells', 'Institute of Beasts' project - a project designed to temporarily house what the artists' describe as their more errant or wild thoughts. The works in the exhibition include objects, texts, animations and sound works which form an installation, both elegant and disturbing, that encodes a wide range of references. Stemming from the idea of an institute being something ordered and organized whereas 'Beasts' are unknown, erratic and mythologized, Dutton and Swindells divide their institute into conceptual departments, imposing a kind of idiosyncratic order, a gesture perhaps toward taming the erratic. Animated geometric forms and texts sit alongside inverted flower photographs, wall-drawings refer to celestial alignments, sound and music works are built by graphically re-interpreting activist slogans, a computer reads a pathetic and confessional soliloquy and a wall text appropriates spam e-mails selling 'Viagra'. The project has evolved into a multi-layered collage in which inconclusiveness and doubt are prioritized over empirical certainties, forming the critical sentiment that lies at the heart of the project. 'The Institute of Beasts' creates its own strange, yet strategic world-view with its chaotic aesthetic and sceptical notions of knowledge or knowing. For this outing of the project 'The Stag and Hound' the artists will install the exhibition ready for the launch on 20th January and then from 20th January - 16th February will be 'in residence' altering and shifting the exhibition, creating new works and points of resonance between existing works. The title references a tapestry 'The Stag Hunt' housed at the Cluny Museum in Paris in which the stag represents everyman and is hounded by dogs which represent the pitfalls in life such as desire, age or illness. Following on from previous installments of the Institute project such as 'The Dog and Duck' at the Kookmin Art Gallery, Seoul, S.Korea, the title of the show at PSL could also be the name of a pub, suggesting a space of potential conviviality but also of unexpected encounters.